Kickoff: Monday, 8:35 p.m. ET
Line: Indianapolis -3, Total: 54

The Colts attempt to avoid an 0-2 start when they host the Eagles on Monday night.

Here is the BetDSI Sportsbook betting preview for this matchup:

Philadelphia got into trouble in Week 1 with a 17-0 deficit to the 9.5-point underdog Jaguars, but came out a completely different team in the second half, scoring 34 straight points to win 34-17. The club cannot afford to fall behind by that much against Indianapolis, which is a way more talented offense than the Jaguars, so zero points in the second half for Andrew Luck and company is rather unrealistic. The Colts trailed the Broncos 31-10 early in the fourth quarter of their season opener, but cut the lead to 31-24 with just over three minutes remaining. Luck threw for 370 yards with two touchdowns in the game, but was not able to bring his team back to tie it. Indy would be wise to ground-and-pound a little against the Eagles, as slowing the game down could disrupt Chip Kelly’s up-tempo offense. Since 1992, the Colts are 4-2 SU and 5-1 ATS (2-1 SU and ATS on road) versus the Eagles. Indianapolis is also 10-0 ATS in the past three seasons at home where the Total is at least 45.5 points. However, the Eagles are 21-14 ATS (60%) on Monday night since 1992. On the injury front, Indianapolis lost LB Robert Mathis (Achilles) for the season, and might be without four other key defensive players on Monday who are all questionable -- LB Jerrell Freeman (hamstring), CB Greg Toler (ribs), DE Arthur Jones (shoulder) and DB Sergio Brown (shoulder). The Eagles placed a couple of offensive linemen on IR this week (OT Allen Barbre and G Evan Mathis), but there are no other significant injuries to their squad.

Can the Eagles start the season 2-0 with an upset win? For the answer, connect to NFL Best Bets for all the StatFox Experts picks throughout the 2014 regular season and playoffs. During the 2013 campaign, the experts combined for a 52% ATS success rate in NFL Best Bets, highlighted by Brian's 60% ATS mark (41-27-6). Scott had a 54% ATS accuracy (36-31-3) on NFL Best Bets, while Gary was 53% ATS (26-23-3). Scott also thrived with his NFL Totals, finishing at 56% (40-31), capped off by a perfect 5-0 run in the postseason. Brian started the 2014 season with a perfect 3-0 record on NFL Totals and a 3-2 ATS mark in Best Bets for Week 1.

The Eagles pressed the snooze button early on against the Jaguars, but finally awakened in the second half. QB Nick Foles was a disaster early on with an interception and two lost fumbles in the first half, but he found his groove early in the third. Foles finished the game with 322 passing yards and two touchdowns, and should have success against a beatable Colts secondary that allowed 6.92 yards per pass attempt last year (21st in NFL). Last season's rushing champ, RB LeSean McCoy, had 21 carries for only 74 yards (3.5 YPC) against the Jaguars, but did catch six passes for 41 yards in the passing game. New teammate RB Darren Sproles rushed for 71 yards on 11 carries (6.5 YPC) with a touchdown in the game, and also caught four passes for 14 yards. These two backs will see a lot of action against the Colts, whose rushing defense is prone to giving up big plays. Philly's run defense was excellent versus the Jaguars, allowing only 64 yards on 25 carries (2.6 YPC). Where the Eagles will need to improve is their defense against the pass. They allowed Chad Henne to throw for 266 yards with two touchdowns and zero interceptions in their opener, and Andrew Luck is a far superior quarterback that Henne is, and he will make them pay if they don’t improve their coverage.

QB Andrew Luck did everything he could to bring his Colts team back into the game against Denver in Week 1, but the comeback fell just short. The good news is that Luck was able to make a ton of plays in the passing game and also rushed for 19 yards and a touchdown on five attempts. He should have no problem lighting up a far inferior Eagles secondary. WR Reggie Wayne caught nine passes for 98 yards in his first game since undergoing surgery on a torn ACL. He should be able to repeat his success against Philadelphia’s defense. One area that must improve is the rushing offense. The Colts are a team that likes to pound the ball, but RB Trent Richardson rushed for only 20 yards on six carries against the Broncos. Indianapolis will need to establish the rush early, so that it can slow down the Eagles offense and prevent Luck from carrying too much of a load for his team. The Colts defense allowed only 102 yards on 32 carries (3.2 YPC) against the Broncos, and if they can do the same against LeSean McCoy and the Eagles then they should be in good shape. Covering the middle of the field will be crucial, because Nick Foles likes to go right at the opposing safeties with deep passes.