Kickoff: Saturday 6:30 p.m. ET
Line: Oregon -12, Total: 56

The marquee game of the week takes place in Eugene on Saturday as No. 3 Oregon plays host to No. 7 Michigan State.

Here is the BetDSI Sportsbook betting preview for this matchup:

The defending Rose Bowl champion Spartans got the 2014 season started off by defeating Jacksonville State, 45-7. Despite taking a big hit below his knee, Spartans QB Connor Cook (12-of-13, 285 yards, 3 TD) was still able to perform at a high level. Michigan State has been known as more of a physical style of team, but is really emerging as a great passing team too. The Spartans have not beaten a Top 25 on the road since defeating Michigan in 2010 (34-17), and will face a team in Oregon that has not lost a home non-conference game since Sept. 20, 2008 to Boise State. The Ducks once again have one of the most explosive offenses in all of the country, and they showed the big-play ability in a 62-13 Week 1 victory against South Dakota. Heisman trophy candidate QB Marcus Mariota produced 310 total yards of offense and four touchdowns, showing that he is still as explosive as player in college football. Mariota has the ability to beat teams with his arm, but also his legs. In the Oregon spread offense, he is the perfect guy to have leading the charge. Oregon can score in any way, as Charles Nelson took back a punt for a 50-yard touchdown last week. With the new playoff system in effect for college football, this is the type of game that both teams need to win in order to show the people making the decisions that they deserve to be in the running. Although Mark Dantonio is 21-6 ATS (78%) on the road after an SU win since taking over the Michigan State program, recent history shows that favorites of 10.5 to 21 points coming off a season in which they won 80% of their games are 45-16 ATS (74%), including 35-11 ATS (76%) in non-conference tilts. Both teams should have their full rosters for this showdown, as RB Jeremy Langford (ankle), WR Macgarrett Kings Jr. (ankle) and OG Travis Jackson (back) are all probable to play. The same goes for Oregon star DB Ifo Ekpre-Olomu, who injured his ankle last week, but has been upgraded to probable.

Can Oregon win comfortably against a strong defensive team like Michigan State? For the answer, connect to College Football Best Bets for all the StatFox Experts picks throughout the 2014 regular season and bowl season. During the 2013 season, StatFox Dave led the experts with a 55% ATS mark (38-31-2), while Gary and Brian both finished with another winning season (51% ATS). StatFox Scott saved his best for last with a 5-2 ATS mark (71%) in college football bowl Best Bets.

The Spartans experienced success against the Pac-12 last season, when they won the Rose Bowl against Stanford. However, the Cardinal are similar to the Big Ten style of football which tries to grind out yards on the ground. Oregon's fast-paced offense is different, and the MSU offense must be ready to put up some points to get the win. The passing game has found its star in WR Tony Lippett, who had four catches for 167 yards and two touchdowns last week. Lippett is not the biggest receiver at 185 pounds, but has the height (6-foot-3) to go up and win the jump-ball battle. However, what makes him so dangerous is his speed, running as fast as any receiver in the country, and is now the focal point of the Spartans passing game. The Oregon secondary is full of guys that can run with Lippett, but his height advantage will allow Cook to take some chances throwing into coverage. The Spartans have one of the best running backs in the country too in RB Jeremy Langford. While he did not put up big numbers in Week 1 with 57 yards on 13 carries, much of that was because of the big lead and getting experience for other players on the team. The best way to keep an explosive offense like the Ducks from putting up numbers is by keeping their offense on the sideline, so look for the Spartans to rely on the legs of Langford to chew up the clock. Per usual, the strength of the MSU team is the defense, which is very similar to Stanford, which has had major success against Oregon in the past two seasons. DE Shilique Calhoun (two tackles and one sack last week) is a relentless pass rusher, but he will be tested in this game. The Spartans are a physical unit, but the Ducks have a lot of guys that have the speed to break it to the outside, and Calhoun will play a big role in not allowing that to happen. CB Darian Hicks is a young ball hawk that is trying to help fill the void left by Darqueze Dennard, and Hicks got off to a nice start in Week 1 with an interception. The Spartans once again have a strong secondary, but you can’t imitate the speed of the Oregon offense in practice.

Mariota is one the top Heisman candidates in the country, and rightfully so after a season of 4,380 total yards and 40 total touchdowns. Every season the Ducks seem to have a new guy emerge in the backfield, and this season it appears to be RB Byron Marshall, who rushed 13 times for 90 yards in the opener, and also added eight catches for 138 yards and two touchdowns. Marshall is a blur when running the ball. At 205 pounds, he also has the size and power to run up the middle. Another guy in the backfield for the Ducks is Royce Freeman who had 75 yards and two touchdowns in his first career game. At 230 pounds, Freeman is built like former Ducks RB LeGarrette Blount. The Ducks have been missing that power element to its rushing attack, but appear to now have the lethal combination of speed and power. While the defense does not get much of the talk in Eugene, there are plenty of playmakers on that side of the ball. The defense is similar to the offense in the sense that it is built on its ability to fly to the ball. It is undersized at a few positions, but everyone on the field for the Oregon defense can run. CB Ifo Ekpre-Olomu is a true playmaker both in coverage and against the run. He will be put on Lippett a lot of this matchup, and that battle could play a huge role in what team is able to get the victory.