| | Statistic | FOR | OPP |
| Total Yards per Game | 355.2 | 327.3 |
| Rushing YDS per ATT | 4.7 | 4.6 |
| Passing YDS per ATT | 7.1 | 6.3 |
| Passing Comp % | 0.657 | 0.613 |
| Total YDS per Play | 6.0 | 5.5 |
| Total YDS per Point | 15.7 | 13.5 |
|
| Injury |
| [DE] Payton Turner (Ankle) - Out [11/20/2022] => Turner was ruled out heading into Week 12 versus the 49ers. |
| [DB] J.T. Gray (Hamstring) - Out [11/17/2022] => Gray was ruled out heading into Week 12 versus the 49ers. |
| [DE] Cameron Jordan (Eye) - Questionable [11/16/2022] => Jordan was a limited participant in practice on Friday heading into Week 12 versus the 49ers. |
| [OL] Andrus Peat (Triceps) - Questionable [11/09/2022] => Peat was a limited participant in practice on Friday heading into Week 12 versus the 49ers. |
| [LB] Pete Werner (Ankle) - Out [11/08/2022] => Werner was ruled out heading into Week 12 versus the 49ers. |
| [OL] Erik McCoy (Calf) - Out (Injured Reserve) [11/08/2022] => McCoy has been placed on the Injured Reserve with a calf injury and will miss at least 4 weeks. |
| [DE] Marcus Davenport (Calf) - Questionable [11/07/2022] => Davenport was a limited participant in practice on Friday heading into Week 12 versus the 49ers. |
| [LB] Chase Hansen (Knee) - Out (Injured Reserve) [11/03/2022] => Hansen has been placed on the injured reserve due to a knee injury, he will miss at least four weeks. |
| [RB] Mark Ingram II (Knee) - Questionable [10/30/2022] => Ingram II was a limited participant in practice on Friday heading into Week 12 versus the 49ers. |
| [CB] Marshon Lattimore (Abdomen) - Questionable [10/09/2022] => Lattimore was a limited participant in practice on Friday heading into Week 12 versus the 49ers. |
| [WR] Deonte Harty (Foot) - Out (Injured Reserve) [10/09/2022] => Harty has been placed on injured reserve and will miss at least four weeks. |
| [WR] Michael Thomas (Foot) - Out (Injured Reserve) [09/25/2022] => Thomas is battling a foot injury and has been placed on injured reserve and will miss a minimum of four weeks. |
| [DT] Albert Huggins (Leg) - Out (Injured Reserve) [08/30/2022] => Huggins has been placed on the injured reserve list due to a leg injury and he will miss the 2022-2023 season. |
| [G] Forrest Lamp (Undisclosed) - Out (Injured Reserve) [08/19/2022] => Lamp has been placed on the injured reserve list and will miss the 2022-2023 season. |
| [LB] Isaiah Pryor (Undisclosed) - Out (Injured Reserve) [08/16/2022] => Pryor has been placed on the injured reserve list and will miss the remainder of the 2022-23 season. |
| [OT] Ethan Greenidge (Knee) - Out (Injured Reserve) [08/15/2022] => Greenidge has been placed on the injured reserve list due a knee injury and will miss the 2022-2023 season. |
| [LB] D'Marco Jackson (Undisclosed) - Out (Injured Reserve) [08/09/2022] => Jackson has been placed on the injured reserve list with an undisclosed injury and will miss the 2022-2023 season. |
| [S] Smoke Monday (Knee (ACL)) - Out (Injured Reserve) [08/05/2022] => Monday has been placed on the injured reserve list due to a torn ACL and will miss the 2022-2023 season. |
| [TE] Dylan Soehner (Undisclosed) - Out (Physically Unable to Perform) [05/16/2022] => Soehner has been placed on the Physically Unable to Perform list with an undisclosed injury. |
