| | Statistic | FOR | OPP |
| Total Yards per Game | 329.5 | 412.0 |
| Rushing YDS per ATT | 4.8 | 5.3 |
| Passing YDS per ATT | 6.0 | 7.9 |
| Passing Comp % | 0.641 | 0.743 |
| Total YDS per Play | 5.6 | 6.8 |
| Total YDS per Point | 22.0 | 26.6 |
|
| Injury |
| [LB] Eric Kendricks (Toe) - Questionable [09/23/2022] => Kendricks was limited in practice on Friday heading into Week 3 versus the Lions. |
| [S] Harrison Smith (Concussion) - Out [09/21/2022] => Smith has been ruled out heading into Week 3 versus the Lions. |
| [CB] Andrew Booth Jr. (Quad) - Out [09/15/2022] => Booth has been ruled out heading into Week 3 versus the Lions. |
| [WR] Blake Proehl (ACL) - Out (Physically Unable to Perform) [08/31/2022] => Proehl is recovering from an ACL Injury and has been placed on the Physically Unable to Perform list. He will miss at least four weeks. |
| [WR] Bisi Johnson (Knee (ACL)) - Out (Injured Reserve) [08/28/2022] => Johnson has been placed on the injured reserve list due to a torn ACL and will miss the 2022-2023 season. |
| [WR] Thomas Hennigan (Undisclosed) - Out (Injured Reserve) [08/17/2022] => Hennigan has been placed on the injured reserve list due to an undisclosed injury and will miss the 2022-2023 season. |
| [LB] Ryan Connelly (Knee (ACL)) - Out (Physically Unable to Perform) [07/25/2022] => Connelly has been placed on the Physically Unable to Perform list while recovering from an ACL injury. He will miss at least four weeks. |
| [DE] Kenny Willekes (Undisclosed) - Out (Injured Reserve) [06/03/2022] => Willekes has been placed on the injured reserve list and will miss the 2022-23 season. |
