| | Statistic | FOR | OPP |
| Total Yards per Game | 427.0 | 372.0 |
| Rushing YDS per ATT | 3.7 | 5.0 |
| Passing YDS per ATT | 8.5 | 8.7 |
| Passing Comp % | 0.711 | 0.712 |
| Total YDS per Play | 6.9 | 7.0 |
| Total YDS per Point | 13.8 | 16.5 |
|
| Injury |
| [OT] Terron Armstead (Toe) - Questionable [09/21/2022] => Armstead did not practice on Friday heading into Week 3 versus the Bills. |
| [CB] Xavien Howard (Groin) - Questionable [09/21/2022] => Howard was limited in practice on Friday heading into Week 3 versus the Bills. |
| [DT] Raekwon Davis () - Questionable [09/21/2022] => Davis was limited in practice on Friday heading into Week 3 versus the Bills. |
| [WR] Cedrick Wilson Jr. (Ribs) - Questionable [09/18/2022] => Wilson Jr. was limited in practice on Friday heading into Week 3 versus the Bills. |
| [TE] Hunter Long (Ankle) - Out [09/16/2022] => Long has been ruled out heading into Week 3 versus the Bills. |
| [OL] Austin Jackson (Ankle) - Out (Injured Reserve) [09/11/2022] => Jackson is dealing with an ankle injury and has been placed on the Injured Reserve. He will miss at least 4 Weeks. |
| [TE] Cethan Carter (Head) - Out [09/11/2022] => Carter has been ruled out heading into Week 3 versus the Bills. |
| [S] Clayton Fejedelem (Undisclosed) - Out (Injured Reserve) [09/01/2022] => Fejedelem has been placed on the injured reserve list due to an undisclosed injury. He will miss at least four weeks. |
| [LB] Calvin Munson (Undisclosed) - Out (Injured Reserve) [08/29/2022] => Munson has been added to the injured reserve due to an undisclosed reason and will miss the 2022-2023 season. |
| [FB] John Lovett (Knee) - Out (Injured Reserve) [08/23/2022] => Lovett has been placed on the injured reserve list due to a knee injury and will miss the 2022-2023 season. |
| [TE] Adam Shaheen (Knee) - Out (Injured Reserve) [08/16/2022] => Shaheen has been placed on the injured reserve list due to a failed physical via a preexisting knee condition and will miss the 2022-2023 season. |
| [CB] Trill Williams (Knee (ACL)) - Out (Injured Reserve) [08/14/2022] => Williams has been placed on the injured reserve list due to a torn ACL and will miss the entire 2022-2023 season. |
| [CB] Byron Jones (Achilles) - Out (Physically Unable to Perform) [07/22/2022] => Jones has been placed on the Physically Unable to Perform list while recovering from an Achilles injury. He will miss at least four weeks. |
