| | Statistic | FOR | OPP |
| Total Yards per Game | 347.5 | 390.6 |
| Rushing YDS per ATT | 4.1 | 4.2 |
| Passing YDS per ATT | 6.6 | 7.3 |
| Passing Comp % | 0.663 | 0.672 |
| Total YDS per Play | 5.6 | 6.1 |
| Total YDS per Point | 14.2 | 16.7 |
|
| Injury |
| [DB] Ja'Sir Taylor (Illness) - Out [11/30/2023] => Taylor has been ruled out heading into Week 13 versus the Patriots. |
| [WR] Keenan Allen (Quad) - Questionable [11/29/2023] => Allen was limited in practice on Friday heading into Week 13 versus the Patriots. |
| [G] Zack Bailey (Back) - Out [11/29/2023] => Bailey has been ruled out heading into Week 13 versus the Patriots. |
| [OT] Trey Pipkins III (Wrist) - Questionable [11/29/2023] => Pipkins III was limited in practice on Friday heading into Week 13 versus the Patriots. |
| [TE] Nick Vannett (Concussion) - Out [11/22/2023] => Vannett has been ruled out heading into Week 13 versus the Patriots. |
| [LB] Tanner Muse (Knee) - Out (Injured Reserve) [11/19/2023] => Muse is dealing with a knee injury and has been placed on the injured reserve list. He will miss at least four games. |
| [OLB] Joey Bosa (Foot) - Out (Injured Reserve) [11/19/2023] => Bosa is dealing with a foot sprain and has been placed on the injured reserve list. He will miss at least four weeks. |
| [OLB] Chris Rumph II (Foot) - Out (Injured Reserve) [11/12/2023] => Rumph II suffered a foot fracture and has been placed on the injured reserve list. He is expected to miss several weeks. |
| [WR] Joshua Palmer (Knee) - Out (Injured Reserve) [11/02/2023] => Palmer is dealing with a knee injury and has been placed on the injured reserve list. He will miss at least four games. |
| [S] Raheem Layne (Knee) - Out (Injured Reserve) [10/16/2023] => Layne has suffered a torn ACL and has been placed on the injured reserve list. He will miss the remainder of the 2023-24 season. |
| [S] JT Woods (Illness) - Questionable (Non-Football Illness) [09/29/2023] => The Chargers have opened the 21-day practice window for Woods as they await his return from the non-football illness list. |
| [C] Corey Linsley (Heart) - Out (Non-Football Illness) [09/27/2023] => Linsley is battling a heart issue has been placed on the non-football illness list. He will miss at least four games. |
| [WR] Mike Williams (Knee) - Out (Injured Reserve) [09/24/2023] => Williams has suffered a torn ACL and has been placed on the injured reserve list. He will miss the rest of the 2023-2024 season. |
| [OT] Andrew Trainer (Undisclosed) - Out (Injured Reserve) [09/04/2023] => Trainer is dealing with an undisclosed injury and has been placed on the injured reserve list. He will miss the 2023-24 season. |
| [CB] Amechi Uzodinma (Undisclosed) - Out (Injured Reserve) [08/31/2023] => Uzodinma is dealing with an undisclosed injury and has been placed on the injured reserve list. He will miss the 2023-24 season. |
