| | Statistic | FOR | OPP |
| Total Yards per Game | 403.5 | 341.5 |
| Rushing YDS per ATT | 4.9 | 3.9 |
| Passing YDS per ATT | 7.9 | 5.9 |
| Passing Comp % | 0.730 | 0.663 |
| Total YDS per Play | 6.8 | 5.2 |
| Total YDS per Point | 11.4 | 15.2 |
|
| Injury |
| [LB] Willie Gay (Suspended) - Out (Suspended) [09/19/2022] => Gay has been suspended for four games for violating the league's personal conduct policy. |
| [DE] Mike Danna (Calf) - Out [09/15/2022] => Danna has been ruled out heading into Week 3 versus the Colts. |
| [CB] Trent McDuffie (Hamstring) - Out (Injured Reserve) [09/11/2022] => McDuffie has been placed on the injured reserve due to a hamstring injury and will miss at least 4 weeks |
| [K] Harrison Butker (Ankle) - Out [09/11/2022] => Butker has been ruled out heading into Week 3 versus the Colts. |
| [TE] Blake Bell (Hip) - Out (Injured Reserve) [08/30/2022] => Bell has been placed on the injured reserve list due to a hip injury. He will miss at least four weeks. |
| [OT] Lucas Niang (Kneecap) - Out (Physically Unable to Perform) [07/23/2022] => Niang has been placed on the Physically Unable to Perform list while recovering from a kneecap injury. He will miss at least the first four weeks of the 2022-2023 season. |
| [WR] Justyn Ross (Foot) - Out (Injured Reserve) [07/23/2022] => Ross has been placed on the injured reserve list due to a foot injury and will miss the 2022-2023 season. |
