| | Statistic | FOR | OPP |
| Total Yards per Game | 378.7 | 323.7 |
| Rushing YDS per ATT | 5.0 | 4.1 |
| Passing YDS per ATT | 6.1 | 6.9 |
| Passing Comp % | 0.663 | 0.606 |
| Total YDS per Play | 5.5 | 5.9 |
| Total YDS per Point | 13.4 | 13.5 |
|
| Injury |
| [LB] Anthony Walker Jr. (Quad) - Out (Injured Reserve) [09/22/2022] => Walker Jr. has suffered a torn quad and will miss the remainder of the 2022 2023 season. |
| [TE] Jesse James (Biceps) - Out (Injured Reserve) [09/19/2022] => James is dealing with a bicep injury and has been placed on the Injured Reserve. He will miss at least 4 Weeks. |
| [DE] Chase Winovich (Hamstring) - Out (Injured Reserve) [09/19/2022] => Winovich is dealing with a hamstring injury and has been placed on the Injured Reserve. He will miss at least 4 Weeks. |
| [DE] Jadeveon Clowney (Ankle) - Questionable [09/18/2022] => Week 4 |
| [CB] Greedy Williams (Hamstring) - Out (Injured Reserve) [09/09/2022] => Williams has been placed on the injured reserve list due to a hamstring injury. He will miss at least four weeks. |
| [LB] Chris Odom (Knee (ACL)) - Out (Injured Reserve) [08/28/2022] => Odom has been placed on the injured reserved list due to a torn ACL and will miss the remainder of the 2022-2023 season. |
| [OT] Elijah Nkansah (Undisclosed) - Out (Injured Reserve) [08/17/2022] => Nkansah has been placed on the injured reserve list and will miss the remainder of the 2022-23 season. |
| [G] Dawson Deaton (ACL) - Out (Injured Reserve) [08/15/2022] => Deaton has been placed on the injured reserve list due a torn ACL and will miss the 2022-2023 season. |
| [C] Nick Harris (Knee) - Out (Injured Reserve) [08/13/2022] => Harris has been placed on the injured reserve list due to a knee injury and will miss the 2022-2023 season. |
| [WR] Jakeem Grant Sr. (Achilles) - Out (Injured Reserve) [08/10/2022] => Grant has been placed on the injured reserve list due to a torn Achilles and will miss the 2022-2023 season. |
| [DE] Stephen Weatherly (Knee) - Out (Injured Reserve) [08/06/2022] => Weatherly has been placed on the injured reserve list due to a knee injury and will miss the 2022-2023 season. |
| [WR] Isaiah Weston (Knee) - Out (Injured Reserve) [08/02/2022] => Weston has been placed on the injured reserve list due to a meniscus injury and will miss the 2022-2023 season. |
| [QB] Deshaun Watson (Suspension) - Out (Suspended) [08/01/2022] => Watson has been suspended 11 regular season games for violating the NFL's personal conduct policy. He is eligible to return in Week 13 pending reinstatement by the league. |
